GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs2243480 | 1 | rs1267820 | chr7:66050295 | LOC493754 | chr7:65993446-66057363:- | 0.24 | 4.06 | 5.29E-5 | Diabetic kidney disease |
| BRCA | cis | rs12691307 | 1 | rs12691307 | chr16:29939877 | ALDOA | chr16:30064472-30081734:+ | 0.11 | 3.71 | 0.000215 | Schizophrenia |
| BRCA | cis | rs12691307 | 1 | rs12691307 | chr16:29939877 | BOLA2 | chr16:29454226-29466285:-;chr16 | -0.12 | -4.68 | 3.17E-6 | Schizophrenia |
| BRCA | cis | rs12691307 | 1 | rs12691307 | chr16:29939877 | GDPD3 | chr16:30116132-30124878:- | -0.12 | -3.62 | 0.000307 | Schizophrenia |
| BRCA | cis | rs12691307 | 1 | rs12691307 | chr16:29939877 | LOC595101 | chr16:30278914-30346695:- | -0.16 | -4.16 | 3.44E-5 | Schizophrenia |
| BRCA | cis | rs12691307 | 1 | rs12691307 | chr16:29939877 | MAPK3 | chr16:30125427-30134630:- | -0.12 | -3.7 | 0.000226 | Schizophrenia |
| BRCA | cis | rs12691307 | 1 | rs12691307 | chr16:29939877 | RUNDC2C | chr16:29339874-29418349:+ | 0.12 | 3.99 | 6.98E-5 | Schizophrenia |
| BRCA | cis | rs6738627 | 1 | rs12692737 | chr2:165554309 | SLC38A11 | chr2:165754812-165812035:- | 0.17 | 5.11 | 3.75E-7 | circulating leptin levels;circulating leptin levels adjusted for BMI;Body fat percentage |
| BRCA | cis | rs2243480 | 1 | rs12698509 | chr7:65418876 | CCT6P1 | chr7:65216092-65228661:+ | 0.32 | 7.24 | 8.88E-13 | Diabetic kidney disease |
| BRCA | cis | rs2243480 | 1 | rs12698509 | chr7:65418876 | LOC493754 | chr7:65993446-66057363:- | 0.21 | 3.58 | 0.000357 | Diabetic kidney disease |
| BRCA | cis | rs2243480 | 1 | rs12698509 | chr7:65418876 | ZNF117 | chr7:64434830-64467121:- | -0.25 | -4.75 | 2.33E-6 | Diabetic kidney disease |
| BRCA | cis | rs14978 | 1 | rs12699336 | chr7:12283250 | VWDE | chr7:12370509-12443852:- | -0.14 | -3.8 | 0.000153 | Response to amphetamines |
| BRCA | cis | rs1668357 | 1 | rs12701600 | chr7:37998848 | EPDR1 | chr7:37960163-37991539:+ | -0.2 | -3.48 | 0.000527 | Myopia (pathological) |
| BRCA | cis | rs13240464 | 1 | rs12705762 | chr7:111039799 | IMMP2L | chr7:110303110-111202538:- | 0.14 | 3.69 | 0.000237 | Schizophrenia |
| BRCA | cis | rs2836974 | 1 | rs12710454 | chr21:40656919 | HMGN1 | chr21:40714247-40721270:- | -0.18 | -4.66 | 3.53E-6 | Cognitive function |